![]() ![]() ![]() A custom label free optical contrast based on polarization-dependent scattered lightsheet microscopy was applied to cleared bladders to confirm tumor penetration by nanobots. Inductively coupled plasma mass spectrometry confirmed these results. Positron emission tomography revealed an 8-fold increase in accumulation in vivo. In vivo and ex vivo results demonstrate enhanced accumulation of nanobots at the tumor site. Here, we radiolabeled mesoporous silica-based urease-powered nanobots for imaging purposes and tested them in an orthotopic murine model of BC. Self-propelled nanoparticles (nanobots) could overcome these limitations through their enhanced diffusion and mixing capabilities in urine compared to conventional drugs or passive nanoparticles. Current treatment methods involving intravesical drug administration present good survival rates but low therapeutic efficacy. work is licensed under a CC BY 4.0 LicenseStatus:Under ReviewVersion 1posted 28 Mar, 2023You are reading this latest preprint versionAbstractBladder cancer (BC) is among the most common cancers worldwide. It’s small footprint will save valuable space in the lab and it can be easily integrated into larger third party systems.Radionuclide therapy based on accumulated urease-powered nanobots in the bladder tumor of an orthotopic murine model | Research Square BrowsePreprintsCOVID-19 PreprintsProtocolsVideosJournalsTools & ServicesOverviewDigital EditingProfessional EditingBadgesResearch PromotionYour CartAboutPreprint PlatformIn ReviewEditorial PoliciesOur TeamAdvisory BoardBlogHelp CenterSign InSubmit a PreprintCiteShareDownload PDFArticleRadionuclide therapy based on accumulated urease-powered nanobots in the bladder tumor of an orthotopic murine modelCristina Simó, Meritxell Serra-Casablancas, Ana Hortelao, Valerio Di Carlo, and 14 moreThis is a preprint it has not been peer reviewed by a journal. The Sci-Print MP2 can print a range of standard barcodes including 1D and 2D formats. The Sci-Print MP2 is a semi-automated microplate barcode label printer that prints and applies labels onto a variety of microtiter plates for sample tracking.Some of it’s features include removable stackers for easy loading and unloading, fast cycle times to increase efficiency and productivity, and full diagnostic and test utilities for easy troubleshooting. The Sci-Print MP2+ is a fully-automated microplate barcode labele printer for use with a variety of SBS footprint microplates and deepwell blocks.The Sci-Print SOLO can label tubes ranging from 0.5 mL to 50 mL. ![]() A semi-automated tube labeler that can be used stand alone or integrated into larger systems.This unit was designed to be paired with our existing tube labeling machines- the Sci-Print VX2 and the Sci-Print VXL. The VXQ is compatible with a range of tubes from 0.5 mL to 15 mL. The Scinomix VXQ is a bulk vial handler that sorts and feeds bulk tubes for labeling, filling, uncapping and recapping.Some of it’s features include filling and cherry picking, uncapping and capping of screw top lids, and the ability to handle honeycomb plates. The Sci-Print VXL is a fully automated tube labeling machine with a 12 position SBS work deck that can label a variety of tubes including microtubes, cryovials, and vacutainers ranging in size from 0.5 mL to 50 mL.It’s features include filling and cherry picking, uncapping and capping of screw top lids, and the ability to handle honeycomb plates. The Sci-Print VX2 is fully-automated tube labeling machine with a 6 position SBS work deck that can label a variety of tubes including microtubes, cryovials, and vacutainers ranging in size from 0.5 mL to 50 mL.Below are our standard line of tube labelers and microplate labelers that have provided solutions for many customers in the Life Science Industry for a variety of applications. Our products can operate stand alone or be integrated into larger systems. Scinomix has experience in labeling tubes, microplates, deepwell blocks, and many different types of vials including Matrix, Micronic, Cryovials. ![]()
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